Sodium Dehydroacetate
C8H7NaO4
190.13
2H-Pyran-2,4(3H)-dione,3-acetyl-6-methyl-,monosodium salt [4418-26-2].
»Sodium Dehydroacetate contains not less than 98.0percent and not more than 100.5percent of C8H7NaO4,calculated on the anhydrous basis.
Packaging and storage—
Preserve in well-closed containers.
Identification—
A:
Dissolve about 1.5g in 10mLof water,add 5mLof 3Nhydrochloric acid,collect the crystals by filtration with suction,wash with 10mLof water,and dry at 80
for 4hours:the crystals so obtained melt between 109and 111(see Melting Range or Temperature á741ñ).
for 4hours:the crystals so obtained melt between 109and 111(see Melting Range or Temperature á741ñ).
B:
Asolution (1in 20)responds to the tests for Sodium á191ñ.
Water,Method Iá921ñ:
between 8.5%and 10.0%.
Heavy metals,Method IIá231ñ:
0.001%.
Organic volatile impurities,Method Iá467ñ:
meets the requirements.
Assay—
Transfer to a 125-mLconical flask about 500mg of Sodium Dehydroacetate,accurately weighed,dissolve it in 25mLof glacial acetic acid containing p-naphtholbenzein TSwhich has been previously neutralized to a blue color,and titrate with 0.1Nperchloric acid VSto the original blue color.Each mLof 0.1Nperchloric acid is equivalent to 19.01mg of C8H7NaO4.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 3077
Phone Number:1-301-816-8262