Phenylmercuric Acetate
;)
Mercury,(acetato-O)phenyl-.
(Acetato)phenylmercury [62-38-4].
»Phenylmercuric Acetate contains not less than 98.0percent and not more than 100.5percent of C8H8HgO2.
Packaging and storage—
Preserve in tight,light-resistant containers.
Identification—
A:
Add 0.5mLof nitric acid to 0.1g of it,warm gently until a dark brown color is produced,and dilute with water to 10mL:the characteristic odor of nitrobenzene is evolved.
B:
To 0.1g of it add 0.5mLof sulfuric acid and 1mLof alcohol,and warm:the characteristic odor of ethyl acetate is evolved.
C:
To 5mLof a saturated solution in water add a few drops of sodium sulfide TS:a white precipitate is formed,which turns black when the mixture is boiled and then allowed to stand.
Residue on ignition á281ñ:
not more than 0.2%.
Mercuric salts and Heavy metals—
Heat about 100mg with 15mLof water,cool,and filter.To the filtrate add a few drops of sodium sulfide TS:the resulting precipitate shows no immediate color.
Polymercurated benzene compounds—
Shake 2.0g with 100mLof acetone,and filter.Wash the residue with successive portions of acetone until a total of 50mLis used,then dry the residue at 105
for 1hour,and weigh:the weight of the residue does not exceed 30mg (1.5%).
for 1hour,and weigh:the weight of the residue does not exceed 30mg (1.5%).
Organic volatile impurities,Method IVá467ñ:
meets the requirements.
Assay—
Transfer about 500mg of Phenylmercuric Acetate,accurately weighed,to a 100-mLflask,add 15mLof water,5mLof formic acid,and 1g of zinc dust,and reflux for 30minutes.Cool,filter,and wash the filter paper and the amalgam with water until the washings are no longer acid to litmus.Dissolve the amalgam in 40mLof 8Nnitric acid.Heat on a steam bath for 3minutes,and then add 500mg of urea and enough potassium permanganate TSto produce a permanent pink color.Cool,decolorize the solution with hydrogen peroxide TS,add 1mLof ferric ammonium sulfate TS,and titrate with 0.1Nammonium thiocyanate VS.Each mLof 0.1Nammonium thiocyanate is equivalent to 16.84mg of C8H8HgO2.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 3049
Phone Number:1-301-816-8262