Monothioglycerol
;)
1,2-Propanediol,3-mercapto-.
3-Mercapto-1,2-propanediol [96-27-5].
»Monothioglycerol contains not less than 97.0percent and not more than 101.0percent of C3H8O2S,calculated on the anhydrous basis.
Packaging and storage—
Preserve in tight containers.
Specific gravity á841ñ:
between 1.241and 1.250.
Refractive index á831ñ:
between 1.521and 1.526.
pHá791ñ:
between 3.5and 7.0,in a solution (1in 10).
Water,Method IIá921ñ:
not more than 5.0%.
Residue on ignition á281ñ:
not more than 0.1%.
Selenium á291ñ:
0.003%,a 200-µLtest specimen being used.
Heavy metals,Method IIá231ñ:
0.002%.
Organic volatile impurities,Method IVá467ñ:
meets the requirements.
Assay—
Dissolve about 400mg of Monothioglycerol,accurately weighed,in 50mLof water,and titrate with 0.1Niodine VS,adding 3mLof starch TSas the endpoint is approached.Each mLof 0.1Niodine is equivalent to 10.82mg of C3H8O2S.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 3040
Phone Number:1-301-816-8262