Benzyl Benzoate Lotion
»Benzyl Benzoate Lotion contains not less than 26.0percent and not more than 30.0percent (w/w)of C14H12O2.
| Benzyl Benzoate | 250mL |
| Triethanolamine | 5g |
| Oleic Acid | 20g |
| Purified Water | 750mL |
| To make about | 1000mL |
Mix the Triethanolamine with the Oleic Acid,add the Benzyl Benzoate,and mix.Transfer the mixture to a suitable container of about 2000-mLcapacity,add 250mLof Purified Water,and shake the mixture thoroughly.Finally add the remaining Purified Water,and again shake thoroughly.
Packaging and storage—
Preserve in tight containers.
pHá791ñ:
between 8.5and 9.2.
Assay—
Place about 5g of Lotion,accurately weighed,in a conical flask.Add 25mLof alcohol and 2drops of phenolphthalein TS.Cool the solution to about 15
,and titrate quickly with 0.1Nsodium hydroxide to a slight pink color.Add 50.0mLof 0.5Nalcoholic potassium hydroxide VS,connect the flask to a reflux condenser,and boil gently for 1hour.Cool,promptly add phenolphthalein TS,and titrate with 0.5Nhydrochloric acid VS.Perform a blank determination (see Residual Titrationsunder Titrimetry á541ñ).Each mLof 0.5Nalcoholic potassium hydroxide is equivalent to 106.1mg of C14H12O2.
,and titrate quickly with 0.1Nsodium hydroxide to a slight pink color.Add 50.0mLof 0.5Nalcoholic potassium hydroxide VS,connect the flask to a reflux condenser,and boil gently for 1hour.Cool,promptly add phenolphthalein TS,and titrate with 0.5Nhydrochloric acid VS.Perform a blank determination (see Residual Titrationsunder Titrimetry á541ñ).Each mLof 0.5Nalcoholic potassium hydroxide is equivalent to 106.1mg of C14H12O2.
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 239
Pharmacopeial Forum:Volume No.30(2)Page 457
Phone Number:1-301-816-8394