Senna
»Senna consists of the dried leaflet of Cassia acutifoliaDelile,known in commerce as Alexandria Senna,or of Cassia angustifoliaVahl,known in commerce as Tinnevelly Senna (Fam.Leguminosae).
Packaging and storage
Preserve against attack by insects and rodents (see Vegetable and Animal DrugsPreservationin the General Notices).
Botanic characteristics
Unground Alexandria Senna
Inequilaterally lanceolate or lance-ovate leaflets,frequently broken;from 1.5cm to 3.5cm in length and from 5mm to 10mm in width,unequal at the base,with very short,stout petiolules.The leaflets are acutely cuspidate,entire,brittle,and subcoriaceous,with short and somewhat appressed hairs,few on the upper surface,more numerous on the lower surface,where they occur spreading on the midrib,especially on its lower part.The color is weak yellow to light grayish green to pale olive.The odor is characteristic.
Unground Tinnevelly Senna
Usually unbroken leaflets,from 2cm to 5cm in length and from 6mm to 15mm in width;acute at the apex;and slightly hairy.The color of the leaves is weak yellow to pale olive.
Histology
Senna shows polygonal epidermal cells with straight walls and frequently containing mucilage;numerous,broadly elliptical stomata mostly from 20to 35µm in length,usually bordered by two neighbor-cells with their long axes parallel to that of the stoma,and rarely,though more frequently in Alexandria Senna,a third epidermal cell at the end of the stoma.The hairs are nonglandular,one-celled,conical,often curved,with thick papillose walls,from 100to 350µm in length.Palisade cells in a single layer underlie both surfaces except in the midrib region where they occur only beneath the upper epidermis.Ameristele occurs in the midrib composed of several radially arranged fibrovascular bundles,the latter separated by narrow vascular rays and supported above and below by arcs of lignified pericyclic fibers.Calcium oxalate occurs in rosette aggregates in the spongy parenchyma and in six-to eight-sided prisms in the crystal fibers,which lie on the outer surface of each group of pericyclic fibers.
Powdered Senna
Dusky greenish yellow to light olive-brown,displaying fragments of veins bearing lignified vessels,tracheids,and crystal fibers,isolated hairs,masses of palisade and spongy parenchyma,fragments of epidermis with stomata,free calcium oxalate rosette aggregates,and prisms from 10to 20µm in length.In powdered Alexandria Senna,the hairs are more numerous than in powdered Tinnevelly Senna.
Identification
Mix 500mg with 10mLof a 1in 10solution of potassium hydroxide in alcohol,boil for about 2minutes,dilute with 10mLof water,and filter.Acidify the filtrate with hydrochloric acid,shake it with ether,remove the ether layer,and shake it with 5mLof 6Nammonium hydroxide:the latter is colored orange or bluish red.
Senna stems,pods,or other foreign organic matter á561ñ
The amount of senna stems does not exceed 8.0%,and the amount of senna pods or other foreign organic matter does not exceed 2.0%.
Acid-insoluble ash á561ñ:
not more than 3.0%.
Auxiliary Information
Staff Liaison:Gabriel I.Giancaspro,Ph.D.,Senior Scientist and Latin American Specialist
Expert Committee:(DSB)Dietary Supplements:Botanicals
USP28NF23Page 1765
Phone Number:1-301-816-8343
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