Packaging and storage— Preserve in well-closed containers.

Identification— Activated Attapulgite responds to the Identificationtest for Colloidal Activated Attapulgite,the characteristic peak,however,being much less intense.

Loss on drying á731ñ— Dry it at 105to constant weight:it loses not more than 4.0%of its weight.

Loss on ignition á733ñ— When ignited at 1000for 1hour,it loses between 4.0%and 12.0%of its weight.

Volatile matter— When ignited at 600for 1hour,it loses between 3.0%and 7.5%of its weight on the dried basis.

Powder fineness— Proceed as directed in the test for Powder finenessunder Colloidal Activated Attapulgite.The dry weight of the residue is not more than 0.10%of the weight of the specimen taken.

Acid-soluble matter— Boil 2.0g with 100mLof 0.2Nhydrochloric acid for 5minutes,and cool.Add water to adjust the volume to 100mL,and filter.Evaporate 50mLof the filtrate so obtained to dryness,and ignite the residue at 600:not more than 0.25g is found (25%).

Organic volatile impurities,Method IVá467ñ: meets the requirements.

Other requirements— It meets the requirements of the tests for Microbial limits,pH,Carbonate,Arsenic and Lead,and Adsorptive capacityunder Colloidal Activated Attapulgite.

Expert Committee:(PA4)Pharmaceutical Analysis 4

USP28–NF23Page 202

Phone Number:1-301-816-8251