Acid medium: 0.1Nhydrochloric acid;900mL.

Dissolution medium: simulated intestinal fluid TS(without enzyme);900mL.

Apparatus 1: 100rpm.

Times: 1hour in Acid medium;1,3,and 7hours in Dissolution medium.

Procedure— Determine the amount of C15H23NO3·HCl dissolved from UVabsorbances at the wavelength of maximum absorption at about 272nm of the first solution under test,suitably diluted with Acid medium,in comparison with a Standard solution having a known concentration of USP Oxprenolol Hydrochloride RSin the same medium.Promptly transfer the basket containing the Tablet to Dissolution medium.After 1,3,and 7hours,respectively,remove 9.0mLof the test solution and determine the amount of C15H23NO3·HCl dissolved from UVabsorbances at the wavelength of maximum absorption at about 272nm of the solution under test,suitably diluted with Dissolution medium,in comparison with a Standard solution having a known concentration of USP Oxprenolol Hydrochloride RSin the same medium.[NOTE—Replace the aliquots withdrawn for analysis with fresh portions of Dissolution medium.]

Tolerances— The percentages of the labeled amount of C15H23NO3·HCl dissolved at the times specified conform to Acceptance Table 1:

Procedure for content uniformity— Proceed as directed for Procedure for the content uniformityin the test for Uniformity of dosage unitsunder Oxprenolol Tablets.