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Atenolol Oral Solution
»Atenolol Oral Solution contains not less than 90.0percent and not more than 110.0percent of the labeled amount of atenolol (C14H22N2O3).Prepare Atenolol Oral Solution at a 0.2%concentration,for example,as follows (see Pharmaceutical Compounding—Nonsterile Preparations á795ñ).
Calculate the quantity of each ingredient required for the total volume and atenolol strength to be prepared.Accurately weigh/measure each ingredient.Mix the Atenolol,previously pulverized,and Glycerin to form a smooth paste.Incorporate the Vehicle for Oral Suspension or an equal volume of Vehicle for Oral Solution,Sugar Free.[NOTE—The Vehicle for Oral Suspension may be omitted.]Incorporate sufficient Vehicle for Oral Solution,Sugar Free in increments to bring to volume,and mix well.[NOTE—Do not use a sucrose-containing vehicle for oral solution.]Package,and label.
Packaging and storage—
Package in amber,tight containers,and store at controlled room temperature.
Labeling—
Label it to state that it is to be shaken well before use,and discarded after 60days.Label it to state that it is to be kept out of reach of children.Label it to indicate the nominal atenolol concentration.
Beyond-use date:
not more than 60days after preparation.
Auxiliary Information—
Staff Liaison:Claudia C.Okeke,Ph.D.,Associate Director
Expert Committee:(CRX)Compounding Pharmacy
USP28–NF23Page 194
Pharmacopeial Forum:Volume No.29(4)Page 1001
Phone Number:1-301-816-8243
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