Vehicle for Oral Suspension
»Prepare Vehicle for Oral Suspension as follows (see Pharmaceutical Compounding—Nonsterile Preparations á795ñ).
| Cellulose,Microcrystalline | 800mg |
| Xanthan Gum | 200mg |
| Carrageenan | 150mg |
| Carboxymethylcellulose Sodium (High Viscosity) |
25mg |
| Citric Acid | 250mg |
| Sodium Phosphate,Dibasic | 120mg |
| Simethicone | 0.1mL |
| Potassium Sorbate | 100mg |
| Methylparaben | 100mg |
| Purified water,a sufficient quantity to make |
100mL |
Calculate the quantity of each ingredient required for the total amount to be prepared.Accurately weigh/measure each ingredient.Heat about 90mLof the Purified Water to 70
to 75.Dissolve the Methylparaben,followed by the Citric Acid,Dibasic Sodium Phosphate,and Potassium Sorbate in the heated water.Remove from the heat.Constantly mixing,slowly sprinkle on the Microcrystalline Cellulose,Xanthan Gum,Carrageenan,and Carboxymethylcellulose Sodium.Continue to stir until fully hydrated,add the Simethicone,and mix well.Add sufficient Purified Water to volume,and mix well.Adjust the pHif necessary.Package,and label.
to 75.Dissolve the Methylparaben,followed by the Citric Acid,Dibasic Sodium Phosphate,and Potassium Sorbate in the heated water.Remove from the heat.Constantly mixing,slowly sprinkle on the Microcrystalline Cellulose,Xanthan Gum,Carrageenan,and Carboxymethylcellulose Sodium.Continue to stir until fully hydrated,add the Simethicone,and mix well.Add sufficient Purified Water to volume,and mix well.Adjust the pHif necessary.Package,and label.
Packaging and storage—
Package in a tight,light-resistant container,and store at controlled room temperature.
Labeling—
Label it to indicate that it is for use in compounding oral solutions and suspensions.
pHá791ñ:
an apparent pHbetween 4.0and 5.0.
Auxiliary Information—
Staff Liaison:Claudia C.Okeke,Ph.D.,Associate Director
Expert Committee:(CRX)Compounding Pharmacy
USP28–NF23Page 3105
Pharmacopeial Forum:Volume No.29(4)Page 1116
Phone Number:1-301-816-8243