Glycine
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Glycine.
Glycine [56-40-6].
»Glycine contains not less than 98.5percent and not more than 101.5percent of C2H5NO2,calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
Identification,Infrared Absorptioná197Mñ.
Loss on drying á731ñ—
Dry it at 105
for 2hours:it loses not more than 0.2%of its weight.
for 2hours:it loses not more than 0.2%of its weight.
Residue on ignition á281ñ:
not more than 0.1%.
Chloride á221ñ—
Asolution of 1.0g in water shows no more chloride than corresponds to 0.10mLof 0.020Nhydrochloric acid (0.007%).
Sulfate á221ñ—
Asolution of 3.0g in water shows no more sulfate than corresponds to 0.20mLof 0.020Nsulfuric acid (0.0065%).
Heavy metals á231ñ:
0.002%.
Hydrolyzable substances—
Boil 10mLof a 1in 10solution of it for 1minute,and set aside for 2hours:the solution appears as clear and as mobile as 10mLof the same solution that has not been boiled.
Organic volatile impurities,Method Iá467ñ:
meets the requirements.
Assay—
Transfer about 150mg of Glycine,accurately weighed,to a 250-mLflask,dissolve in 100mLof glacial acetic acid,add 1drop of crystal violet TS,and titrate with 0.1Nperchloric acid VSto a green endpoint.Perform a blank determination,and make any necessary correction.Each mLof 0.1Nperchloric acid is equivalent to 7.507mg of C2H5NO2.
Auxiliary Information—
Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist
Expert Committee:(DSN)Dietary Supplements:Non-Botanicals
USP28–NF23Page 913
Phone Number:1-301-816-8389