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Standard preparation— Dissolve an accurately weighed quantity of USP Ephedrine Sulfate RSin 0.1Nsulfuric acid to obtain a solution having a known concentration of about 20µg per mL.

Assay preparation— Transfer 5mLof Oral Solution to a separator,add 1mLof 1Nsulfuric acid,and extract with 10mLof chloroform.Discard the extract,and add 5mLof potassium carbonate solution (1in 5).After gas evolution has ceased,extract the solution with three 10-mLportions of chloroform,and combine the extracts in a second separator.Extract the chloroform solution with 50.0mLof 0.1Nsulfuric acid.Filter the acid layer through paper,and dilute 5.0mLof it with 0.1Nsulfuric acid to 100.0mL.

Procedure— Proceed as directed for Procedurein the Assayunder Ephedrine Sulfate Capsules.Calculate the quantity,in mg,of ephedrine sulfate [(C10H15NO)2·H2SO4]in the portion of Oral Solution taken by the formula: in which Cis the concentration,in µg per mL,of USP Ephedrine Sulfate RSin the Standard preparation;and AUand ASare the absorbances of the solutions from the Assay preparationand the Standard preparation,respectively.