Aminobenzoate Potassium Tablets, chemical structure, molecular formula, Reference Standards

Aminobenzoate Potassium Tablets

»Aminobenzoate Potassium Tablets contain not less than 90.0percent and not more than 110.0percent of the labeled amount of aminobenzoate potassium (C7H6KNO2).

Packaging and storage— Preserve in well-closed containers.

USP Reference standards á11ñ— USP Aminobenzoate Potassium RS.

Identification— Proceed as directed for Aminobenzoate Potassium Capsules,using 1g of finely powdered Tablets.

Dissolution á711ñ—

Medium: water;900mL.

Apparatus 1: 100rpm.

Time: 45minutes.

Procedure— Determine the amount of C7H6KNO2dissolved by employing UVabsorption at the wavelength of maximum absorbance at about 270nm on filtered portions of the solution under test,suitably diluted with Medium,in comparison with a Standard solution having a known concentration of USP Aminobenzoate Potassium RSin the same Medium.

Tolerances— Not less than 75%(Q)of the labeled amount of C7H6KNO2is dissolved in 45minutes.

Uniformity of dosage units á905ñ: meet the requirements.

Assay—

Standard preparation— Prepare a solution of USP Aminobenzoate Potassium RShaving a known concentration of about 5µg per mL.

Assay preparation and Procedure—Weigh and finely powder not fewer than 20Tablets.Using a portion of the powdered Tablets,equivalent to about 100mg of aminobenzoate potassium,proceed as directed in the Assayunder Aminobenzoate Potassium Capsules.

Auxiliary Information— Staff Liaison:Clydewyn M.Anthony,Ph.D.,Scientist

Expert Committee:(PA2)Pharmaceutical Analysis 2

USP28–NF23Page 121

Phone Number:1-301-816-8139