Camphor
;)
Bicyclo[2.2.1]heptane-2-one,1,7,7-trimethyl-.
Camphor.
2-Bornanone [76-22-2].
»Camphor is a ketone obtained from Cinnamomum camphora(Linné)Nees et Ebermaier (Fam.Lauraceae)(Natural Camphor)or produced synthetically (Synthetic Camphor).
Packaging and storage—
Preserve in tight containers,and avoid exposure to excessive heat.
Labeling—
Label it to indicate whether it is obtained from natural sources or is prepared synthetically.
Specific rotation á781Sñ:
between +41
and +43,for natural Camphor.
and +43,for natural Camphor.
Test solution:
100mg per mL,in alcohol.
Synthetic Camphor is optically inactive.
Water—
A1in 10solution in solvent hexane is clear.
Limit of nonvolatile residue—
Heat 2.0g in a tared dish on a steam bath until sublimation is complete.Then dry the residue at 120for 3hours,cool,and weigh:the weight of the residue does not exceed 1.0mg (0.05%).
for 3hours,cool,and weigh:the weight of the residue does not exceed 1.0mg (0.05%).
Halogens—
Mix 100mg of finely divided Camphor with 200mg of sodium peroxide in a clean,dry,hard glass test tube of about 25-mm internal diameter and 20-cm length.Suspend the tube at an angle of about 45by means of a clamp placed at the upper end,and gently heat the tube,starting near the upper end,but not heating the clamp,and gradually bringing the heat toward the lower part of the tube until incineration is complete.Dissolve the residue in 25mLof warm water,acidify with nitric acid,and filter the solution into a comparison tube.Wash the test tube and the filter with two 10-mLportions of hot water,adding the washings to the filtered solution.To the filtrate add 0.50mLof 0.10Nsilver nitrate,dilute with water to 50mL,and mix:the turbidity does not exceed that produced in a blank test with the same quantities of the same reagents and 0.050mLof 0.020Nhydrochloric acid (0.035%).
by means of a clamp placed at the upper end,and gently heat the tube,starting near the upper end,but not heating the clamp,and gradually bringing the heat toward the lower part of the tube until incineration is complete.Dissolve the residue in 25mLof warm water,acidify with nitric acid,and filter the solution into a comparison tube.Wash the test tube and the filter with two 10-mLportions of hot water,adding the washings to the filtered solution.To the filtrate add 0.50mLof 0.10Nsilver nitrate,dilute with water to 50mL,and mix:the turbidity does not exceed that produced in a blank test with the same quantities of the same reagents and 0.050mLof 0.020Nhydrochloric acid (0.035%).
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 334
Phone Number:1-301-816-8394